Generally speaking, cigarette smoking increases the risk of breast cancer, but only modestly. However, women who start smoking before their first birth and women who smoke heavily for decades have higher risks. Smoking is also associated with a younger age at breast cancer diagnosis. The evidence generally is mixed for passive smoking. Now a new study has reported that exposures to passive cigarette smoking during vulnerable periods such as the prenatal period and childhood increase subsequent breast cancer risk.
Tobacco smoke contains persistent breast tissue carcinogens such as polycyclic aromatic hydrocarbons (PAHs)and cadmium. Susceptibility to cigarette smoke appears to have a genetic basis - some women do not appear to experience increased breast cancer risk as a result of smoking. Nicotine appears to protect breast cancer cells from programmed cell death, suggesting that electronic cigarettes might also contribute to breast cancer risk. Cigarette smoke has been shown to increase the ability of cancer cells to metastasize. Not surprisingly, smoking is also associated with reduced survival after a diagnosis of breast cancer. The negative effect of smoking on breast cancer survival was found to be highest among women who were normal weight or underweight (BMI < 25) in one study.
High risk smoking
Age of first period has been found to be lower in girls exposed to maternal smoking while in the womb. Numerous studies have found that smoking at a young age contributes disproportionately to breast cancer risk. One study reported that smoking that began before the birth of a woman's first child was associated with an 18% increase in risk of breast cancer for every 20 pack-years smoked. High cumulative smoking exposure also heightens breast cancer risk. Another study reported that women who smoked at least one pack per day for 30 years or more had a 28 percent higher risk than nonsmokers.
Latest research finds periods of heightened vulnerability to cigarette smoke
The large prospective study referenced at the beginning of this news story was designed to investigate the associations between active and passive smoking and breast cancer risk, with an emphasis on exposures during possible periods of increased susceptibility. The study included 50,884 participants in the Sister Study who were enrolled during the period 2003 to 2009. Sister Study participants were U.S. and Puerto Rican women aged 35 to74 who had a sister with breast cancer. Data regarding known breast cancer risk factors, as well as active and passive smoking history (including prenatal and childhood exposures), was collected using telephone interviews and paper questionnaires. The women were followed for breast cancer diagnoses for an average of 6.4 years.
A total of 1,843 study participants were diagnosed with invasive breast cancer during the follow-up period. Exposure to second-hand smoke in adulthood was not found to be linked to increased breast cancer risk. However, nonsmoking women who were exposed to second-hand smoke throughout their childhoods were found to have an 18% higher risk of breast cancer than those without any such exposure during childhood. Prenatal exposure to second-hand smoke was also associated with a modest (16%) increase in breast cancer risk among nonsmokers, as was paternal smoking before the mother's pregnancy (12%). Furthermore, active smoking for at least 10 pack-years prior to first pregnancy was associated with an elevated risk of breast cancer (31%). The authors conclude that both active and passive smoking during potential windows of breast cancer susceptibility, including the prenatal period, childhood, and prior to first pregnancy, are associated with higher risk.