Male breast cancer resembles that of late-onset female breast cancer
Last updated: December 13, 2009
- News type:
- Breast cancer study
- Publication:
- Journal of Clinical Oncology, December 2009
- Study name:
- Male Breast Cancer: A Population-Based Comparison With Female Breast Cancer
A new study compares male breast cancer with female breast cancer. Data from the National Cancer Institute΄s Surveillance, Epidemiology, and End Results (SEER) program was analyzed. Men with breast cancer made up less than 1% of total breast cancer cases. Male breast cancer occurred later in life with higher stage, lower grade, and more estrogen receptor-positive tumors than female breast cancer. Breast cancer incidence and mortality rates have declined in recent years for both men and women, however less so for men. For breast cancer diagnosed during 1996 to 2005, breast cancer death declined by 28% for men and by 42% for women, compared with the period 1976 to 1985. The authors conclude that the biology of male breast cancer resembles that of postmenopausal female breast cancer and that there appear to be common risk factors that affect both sexes, especially in the case of estrogen receptor positive breast cancer. While breast cancer mortality and survival rates have improved significantly in recent decades for both men and women, progress for men has lagged behind that for women.
Studies confirm previous findings concerning male breast cancer
Other studies have also found a similarity between male breast cancer and estrogen-positive postmenopausal breast cancer. Studies have also reported that survival rates for male and female breast cancer are similar, after adjusting for type, stage and grade at diagnosis. Because it is unexpected and typically not screened for, male breast cancer tends to be diagnosed at a more advanced stage when treatments are less effective. One study found that the average duration of symptoms before diagnosis was 16 months. Men should be encouraged to pay attention to the condition of their chest walls and have any lumps, skin changes (ulceration, dimpling or redness), retraction of the nipple, or
nipple discharge medically evaluated.
Selected studies
Male Breast Cancer: A Population-Based Comparison With Female Breast Cancer
Journal of Clinical Oncology, January 2010
The present study was designed to compare male breast cancer with female breast cancer. Case and population data from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program for breast cancers diagnosed between 1973 and 2005 was analyzed. Men with breast cancer made up less than 1% of the breast cancer cases. Compared to female breast cancer, male cases occurred later in life with higher stage, lower grade, and more estrogen receptor-positive (ER+) tumors. Breast cancer incidence and mortality rates have declined in recent years for both men and women, however less so for men. For breast cancer diagnosed in the period 1996 - 2005 compared to 1976 - 1985, breast cancer death declined by 28% for men and by 42% for women, after adjusting for age, breast cancer stage, and tumor grade. The authors conclude that the biology of male breast cancer appears to resemble that of postmenopausal female breast cancer. Furthermore, comparable incidence trends among men and women suggest that there are common risk factors that affect both sexes, especially in the case of ER+ breast cancer. Lastly, breast cancer mortality and survival rates have improved significantly in recent decades for both men and women, but progress for men has lagged behind that for women.
Men With Breast Cancer Have Same Disease-Specific and Event-Free Survival as Women
Annals of Surgical Oncology, April 2009
The current study was designed to compare survival in matched groups of men and women with breast cancer. The study included 58 male breast cancer cases matched with 116 female breast cancer cases; each man was matched with two women. The matching was based on age, year of diagnosis, and breast cancer stage. The chi-square test was used for qualitative data and the t-test was used for quantitative data to compare the two groups. Kaplan-Meier methods were used to calculate overall survival and disease-specific survival. Survival rates between men and women were compared using Cox proportional hazards models. Average age at diagnosis was found to be 63.9 years for men and 65.7 years for women. The median follow-up period was 9.7 years for men and 10.7 years for women. Five-year overall survival was 58.9% for the men compared to 68.2% for the women. Ten-year overall survival was 33.9% for the men versus 52.1% for the women. The men had a significant risk of dying compared to the women (hazard ratio (HR) = 1.59; 95% confidence interval (CI) = 1.04 - 2.42). However, there was no statistically significant differences in disease-specific survival rates. Five-year disease-specific survival was 73.0% for the men and 72.8% for the women. Ten-year disease-specific survival was 55.1% for the men and 61.2% for the women. No significant difference in disease-specific survival between the two matched groups was found (HR = 1.26; 95% CI = 0.76 - 2.10). The authors conclude that the prognosis of men with breast carcinoma is comparable to that of women with similar-stage disease.
<< Previous
Top
Next >>