watercress

Watercress is recommended for breast cancer

Like kale, broccoli, and horseradish, watercress (Nasturtium officinale) is a brassica vegetable. Watercress is a good dietary source of vitamin C, vitamin A, vitamin K, calcium, and various other minerals. Watercress has been shown to have antioxidant, antigenotoxic, and anti-inflammatory properties, and to improve cholesterol profile. Watercress contains beta-carotene, lutein, zeaxanthin, kaempferol, nasturtiin (the precursor of phenethyl isothiocyanate), sulforaphane, phenylethyl isothiocyanate and various other isothiocyanates, all of which have been reported to have anti-cancer properties. Brassica vegetables have been shown to inhibit the growth of human pancreatic cancer cells and to reduce the risk of occurrence of lung, gallbladder, bladder, prostate, ovarian and colorectal cancer.

Various isothiocyanates derived from watercress have been found to have chemopreventive activity against a variety of breast cancer cell lines in the laboratory and in epidemiologic studies. A Chinese study which measured urinary isothiocyanate levels as a marker of brassica vegetable intake found that higher levels were protective against breast cancer in both premenopausal and postmenopausal women. Sulforaphane has been shown to act as a histone deacetylase (HDAC) inhibitor. HDAC inhibitors have been found to increase the effectiveness of the anti-estrogen drug tamoxifen by causing a synergistic increase in apoptosis and cell death.

Watercress can take the place of lettuce in salads or sandwiches. It should be eaten raw rather than cooked to obtain the most powerful anti-cancer effects.

Consuming watercress could interfere with Warfarin (coumadin) and other blood-thinning therapy. Watercress can also reduce the bioavailability of iodine in the diet.

Tags: Chinese, angiogenesis, aromataseActivity, betaCarotene, calcium, carotenoids, inflammation, isothiocyanates, kaempferol, lettuce, ovarianCancer, sulforaphane, tamoxifen, vitaminA, vitaminC, watercress

Carotenoid intakes and risk of breast cancer defined by estrogen receptor and progesterone receptor status: a pooled analysis of 18 prospective cohort studies Kaempferol protects against doxorubicin-induced cardiotoxicity in vivo and in vitro Natural isothiocyanates: Genotoxic potential versus chemoprevention Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice Glucoraphanin hydrolysis by microbiota in the rat cecum results in sulforaphane absorption Inhibition of hypoxia inducible factor by phenethyl isothiocyanate In vivo modulation of 4E binding protein 1 (4E-BP1) phosphorylation by watercress: a pilot study Modulation of detoxification enzymes by watercress: in vitro and in vivo investigations in human peripheral blood cells HDAC inhibitors trigger the autophagic switch from prosurvival to prodeath in tamoxifen-treated breast cancer cells Regulation of estrogen receptor α expression in human breast cancer cells by sulforaphane Cruciferous vegetables, the GSTP1 Ile105Val genetic polymorphism, and breast cancer risk Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells Dietary Organic Isothiocyanates Are Cytotoxic in Human Breast Cancer MCF-7 and Mammary Epithelial MCF-12A Cell Lines Urinary Isothiocyanate Levels, Brassica, and Human Breast Cancer



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