seaweed

Seaweed is recommended for breast cancer in moderation

The category of seaweed, or ocean vegetables, includes edible seaweed or algae such as dulse, kelp (including arame, kombu, and wakame), nori, and sea lettuce (Ulva lactuca and Monostroma spp.). Generally speaking, seaweed is a good dietary source of calcium, iodine, iron, potassium, and fiber. Various seaweeds have been shown to have anti-inflammatory, antioxidant, anticoagulant, and antibiotic properties. Some varieties are also good sources of vitamin A, vitamin B12, vitamin C, vitamin E, vitamin K, manganese, magnesium, selenium, copper, or zinc. Seaweed can be a rich source of carotenoids. For example, brown seaweeds contain beta-carotene, fucoxanthin, and violaxanthin. In addition, seaweed contains some unique compounds, such as various fucoidans (found in brown seaweeds), stearidonic acid (brown seaweeds), phlorotannins (kelp), mycosporine-like amino acids and phenolic acid (dulse), all of which have been shown to have anticancer properties in the laboratory. Various extracts of seaweed have been shown to inhibit the growth of colon and breast cancer cells in the laboratory.

The evidence that seaweed consumption could reduce the risk of breast cancer is based primarily on studies of brown seaweeds:

  • Consumption of brown seaweeds has been shown to favorably alter estrogen metabolism in women. Extract of common kelp has been shown to inhibit the binding of estradiol to estrogen receptors and progesterone to the progesterone receptor. Bladderwrack (another type of edible kelp) has been found to exert anti-estrogenic effects in pre-menopausal women
  • Specific unique components (fucoidan, fucoxanthin, alginic acid, laminarin) of brown seaweeds have been shown to inhibit cancer cell proliferation. However, red seaweeds, which lack these compounds, also inhibit proliferation, suggesting that other compounds found in seaweed may also be important
  • Seaweed in the Asian diet may enhance intestinal conversion of phytoestrogens, in particular the production of equol, which could explain some of the breast cancer protective effects of dietary seaweed and soy
  • The brown seaweed wakame (a type of kelp) has been shown to contain the omega-3 fats eicosapentaenoic acid and stearidonic acid, which may favorably increase the omega-3/omega-6 polyunsaturated fatty acid ratio (which in turn is thought to reduce breast cancer risk). Some other types of seaweed have been found to contain docosahexaenoic acid, another marine omega-3 fat
  • Wakame was also found to reduce breast cancer proliferation in rats in one Japanese study
  • Mekabu (wakame root) extract has been shown to induce cell death in human hormone receptor negative (ER-/PR-) breast cancer cells and to suppress mammary carcinogenesis in rats when administered in daily drinking water, without toxicity
  • Various types of red, brown and green algae have been found to be good sources of melatonin. Melatonin protects against breast cancer in several ways, including by reducing aromatase activity within the breast, thereby reducing estrogen production
  • The relatively high iodine content of seaweed may contribute to reduction in risk of breast cancer
  • The relatively high levels of calcium found in seaweed are also thought to contribute to seaweed's chemopreventive effects, in combination with its other components.

We suggest consuming seaweed as food rather than fucoidan, kelp or other seaweed supplements since (1) as outlined above, various components of seaweed in addition to fucoidan or iodine may be responsible for seaweed's apparent anti-carcinogenic effects; (2) the compounds, minerals and fiber found in seaweed may act synergistically to reduce cancer risk; (3) safe and effective levels of fucoidan have not been established; (4) supplementation may result in increased blood thinning, depending on the formulation.

Most seaweed is dried after being harvested and must be rehydrated before use. Nori is a common seaweed ingredient in sushi. Currently, in the U.S., seaweeds are used mainly as a source of gums, gelling compounds and thickeners (such as agar) for use in foods such as ice cream, and some industrial applications.

Seaweed readily incorporates minerals from the surrounding water; minerals can account for more than one-third of seaweed dry matter. While this can make various seaweeds a rich source of beneficial micronutrients, it can also make them a dietary source of heavy metals, including arsenic. One analysis of dried seaweed samples purchased in London and over the Internet found that some contained unacceptable levels of arsenic. On the other hand, one study found that wakame is effective in preventing the absorption and reabsorption of dioxin from the gastrointestinal tract and therefore might be useful in treatment of humans exposed to dioxin.

Several types of freshwater microalgae, including spirulina and other types of blue-green algae, have been marketed as supplements in the U.S. since the early 1980s. Blue-green algae contain the omega-3 fatty acid alpha-linolenic acid, which has been shown to have chemopreventive activities. However, such freshwater algae can also contain concentrated amounts of heavy metals, as well as toxic microcystins, depending on where it is grown. Whether or not they contain heavy metals, many microalgaes are not edible. In fact, they may be harmful if consumed, and there have been instances of microalgae supplements sold that turned out to be toxic. Therefore, consumers of such supplements should assure themselves of the reputability of the manufacturer.

Since seaweeds have varying amounts of iodine and other nutrients, it can be difficult to know how much is in any given supplement. People with thyroid disorders may find that their conditions are made worse by eating kelp or taking seaweed supplements. Some seaweed also contains large amounts of sodium, which can worsen high blood pressure for those susceptible.

Below are links to recent studies concerning this food. For a more complete list, including less recent studies, please click on seaweed.

Tags: betaCarotene, calcium, carotenoid, daidzein, docosahexaenoicAcid, eicosapentaenoicAcid, equol, estradiol, fiber, fucoidan, genistein, inflammation, iodine, iron, melatonin, omega3, omega6, phytoestrogens, progesterone, proliferation, seaweed, selenium, thyroid, vitaminA, vitaminC, vitaminE

Specific carotenoid intake is inversely associated with the risk of breast cancer among Chinese women Effect of Melatonin on Tumor Growth and Angiogenesis in Xenograft Model of Breast Cancer Anticancer and Antitumor Potential of Fucoidan and Fucoxanthin, Two Main Metabolites Isolated from Brown Algae Fucoidan extract enhances the anti-cancer activity of chemotherapeutic agents in breast cancer cells Fucoidan induces G1 phase arrest and apoptosis through caspases-dependent pathway and ROS induction in human breast cancer MCF-7 cells Bioprospecting of brown seaweed (Ochrophyta) from the Yucatan Peninsula: cytotoxic, antiproliferative, and antiprotozoal activities Brown seaweed fucoidan: Biological activity and apoptosis, growth signaling mechanism in cancer The fucoidans from brown algae of Far-Eastern Seas: anti-tumor activity and structure-function relationship Fucoidan Inhibited 4T1 Mouse Breast Cancer Cell Growth In Vivo and In Vitro Via Downregulation of Wnt/β-Catenin Signaling Comparison of Tamoxifen with Edible Seaweed (Eucheuma cottonii L.) Extract in Suppressing Breast Tumor Screening for in vitro Cytotoxic Activity of Seaweed, Sargassum sp. Against Hep-2 and MCF-7 Cancer Cell Lines Seaweed extracts and unsaturated fatty acid constituents from the green alga Ulva lactuca as activators of the cytoprotective Nrf2-ARE pathway Circulating Carotenoids and Risk of Breast Cancer: Pooled Analysis of Eight Prospective Studies Anticancer Properties and Mechanisms of Fucoidan on Mouse Breast Cancer In Vitro and In Vivo Important Role of β1-Integrin in Fucoidan-Induced Apoptosis via Caspase-8 Activation Therapeutic importance of sulfated polysaccharides from seaweeds: updating the recent findings Cytoprotective effects of fucoidan, an algae-derived polysaccharide on 5-fluorouracil-treated dendritic cells Quinones and halogenated monoterpenes of algal origin show anti-proliferative effects against breast cancer cells in vitro Anti-Inflammatory and Antiproliferative Activities of Organic Fractions from the Mediterranean Brown Seaweed, Cystoseira compressa Fucoidan Extract Induces Apoptosis in MCF-7 Cells via a Mechanism Involving the ROS-Dependent JNK Activation and Mitochondria-Mediated Pathways



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