raspberries

Raspberries are highly recommended for breast cancer

Raspberries are rich in phenolic phytochemicals, including ellagitannin and anthocyanins, which have been shown to have anti-inflammatory, chemopreventive, antiproliferative and proapoptic effects. Raspberries are also a good dietary source of the lignan enterolactone.

Breast cancer-related effects of eating raspberries

Raspberry powder has been shown to have antiproliferative effects when fed to female rats prone to mammary tumors. Black raspberries appear to have more cancer-preventative chemicals than the closely-related red raspberries. Studies that have compared blueberry and black raspberry diets in rats have found that while blueberries result in lower tumor volume than black raspberries, black raspberries are more effective in delaying the first appearance of tumors in rats implanted with estradiol.

Ellagic acid, found in raspberries, has been shown to inhibit breast cancer in cell and animal studies, in part by inhibiting angiogenesis. Cancer cells induce angiogenesis during the early stages of tumor development this is a crucial step that separates preinvasive and dormant forms of cancer from invasive and metastatic malignant growth.

Additional comments

Non-organic raspberries must be washed very thoroughly to remove pesticide residue. Loganberries are a hybrid cross between between a blackberry and a raspberry.

Below are links to recent studies concerning this food. For a more complete list, including less recent studies, please click on raspberries.

Tags: angiogenesis, anthocyanins, blackberry, ellagicAcid, enterolactone, inflammation, lignan, proliferation, raspberry

Selected breast cancer studies

Anthocyanins potentiate the activity of trastuzumab in human epidermal growth factor receptor 2‑positive breast cancer cells in vitro and in vivo Bioactive compounds or metabolites from black raspberries modulate T lymphocyte proliferation, myeloid cell differentiation and Jak/STAT signaling Ellagic Acid Exerts Anti-proliferation Effects via Modulation of Tgf-β/Smad3 Signaling in MCF-7 Breast Cancer Cells NMR-Based Metabolomic Investigation of Bioactivity of Chemical Constituents in Black Raspberry (Rubus occidentalis L.) Fruit Extracts Nonanthocyanin Secondary Metabolites of Black Raspberry (Rubus occidentalis L.) Fruits: Identification by HPLC-DAD, NMR, HPLC-ESI-MS, and ESI-MS/MS Analyses Resveratrol enhances chemosensitivity of doxorubicin in multidrug-resistant human breast cancer cells via increased cellular influx of doxorubicin Anticancer effects of bioactive berry compounds Quercetin suppresses invasion and migration of H-Ras-transformed MCF10A human epithelial cells by inhibiting phosphatidylinositol 3-kinase Vitamin C intake and breast cancer mortality in a cohort of Swedish women Cytotoxicity and apoptosis induction in human breast adenocarcinoma MCF-7 cells by (+)-cyanidan-3-ol The gut microbiota ellagic acid-derived metabolite urolithin A, and its sulfate conjugate, are substrates for the drug efflux transporter breast cancer resistance protein (ABCG2/BCRP) Effect of Berry Extracts and Bioactive Compounds on Fulvestrant (ICI 182,780) Sensitive and Resistant Cell Lines Persistence of Anticancer Activity in Berry Extracts after Simulated Gastrointestinal Digestion and Colonic Fermentation The Effect of Quercetin On Doxorubicin Cytotoxicity in Human Breast Cancer Cells Inhibition of estrogen-mediated mammary tumorigenesis by blueberry and black raspberry Ellagic acid, a phenolic compound, exerts anti-angiogenesis effects via VEGFR-2 signaling pathway in breast cancer Influence of Berry-Polyphenols on Receptor Signaling and Cell-Death Pathways: Implications for Breast Cancer Prevention Chemoprevention of mammary carcinogenesis by sustained systemic delivery of ellagic acid Serum enterolactone levels and mortality outcome in women with early breast cancer: a retrospective cohort study Anti-Inflammatory Effects of Polyphenolic-Enriched Red Raspberry Extract in an Antigen Induced Arthritis Rat Model Cold-field fruit extracts exert different antioxidant and antiproliferative activities in vitro

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