highly recommended for breast cancer
Grapes contain polyphenols (resveratrol, quercetin, and catechin) that can act as antioxidants, antiangiogenics, and selective estrogen receptor modifiers. Each of these polyphenols have been found to have chemopreventative properties. Grapes also contain lupeol, pterostilbene, and fisetin, which also have been shown to have anti-cancer properties. Green or white grapes have less powerful anticancer properties than red grapes since they contain fewer polyphenols. Note that grape seed oil and grape seed extract are covered in another web page.
Breast cancer-related effects of
Red grapes and grape seeds are a good source of resveratrol, which has the ability to suppress proliferation of breast cancer cells and promote cell death. Resveratrol also can inhibit aromatase (the synthesis of estrogen from androgens within the body), which is important for reducing growth-stimulatory effects in estrogen-dependent breast cancer. Other grape polyphenols such as quercetin and catechin have also been shown to have chemopreventive effects and appear to act synergistically with resveratrol in inhibiting breast cancer growth. Several population studies have reported that grape consumption is associated with reduced risk of breast cancer.
Resveratrol has also been shown to increase the effects of radiation treatment and the chemotherapy drug Taxol (paclitaxel) against breast cancer.
Non-organic (especially imported) grapes must be washed very thoroughly to remove pesticide residue.
Below are links to recent studies concerning this food. For a more complete list, including less recent studies, please click on grapes.
Selected breast cancer studies
Resveratrol prevents p53 core domain aggregation
Regulation of the mammalian target of rapamycin signaling by grape polyphenols in breast cancer
Anticarcinogenic activity of polyphenolic extracts from grape stems against breast, colon, renal and thyroid cancer cells
Resveratrol enhances chemosensitivity of doxorubicin in multidrug-resistant human breast cancer cells via increased cellular influx of doxorubicin
Quercetin suppresses invasion and migration of H-Ras-transformed MCF10A human epithelial cells by inhibiting phosphatidylinositol 3-kinase
Grape seed extract suppresses MDA-MB231 breast cancer cell migration and invasion
Proteomic Profiling Reveals That Resveratrol Inhibits HSP27 Expression and Sensitizes Breast Cancer Cells to Doxorubicin Therapy
Cytotoxicity and apoptosis induction in human breast adenocarcinoma MCF-7 cells by (+)-cyanidan-3-ol
Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF-κB/microRNA 448 circuit
Fisetin regulates obesity by targeting mTORC1 signaling
Anti-estrogenic activity of a human resveratrol metabolite
Resveratrol decreases breast cancer cell viability and glucose metabolism by inhibiting 6-phosphofructo-1-kinase
Resveratrol activates the histone H2B ubiquitin ligase, RNF20, in MDA-MB-231 breast cancer cells
Invadopodia-associated proteins blockade as a novel mechanism for 6-shogaol and pterostilbene to reduce breast cancer cell motility and invasi
Assessment of polyphenolic content, antioxidant activity, protection against ROS-induced DNA damage and anticancer activity of Vitis vinifera stem extracts
Dietary grape polyphenol resveratrol increases mammary tumor growth and metastasis in immunocompromised mice
Cytotoxic Effect of Natural trans-Resveratrol Obtained from Elicited Vitis vinifera Cell Cultures on Three Cancer Cell Lines
Grape Polyphenols Inhibit Akt/Mammalian Target of Rapamycin Signaling and Potentiate the Effects of Gefitinib in Breast Cancer
Antitumor and antimetastatic activities of grape skin polyphenols in a murine model of breast cancer