cauliflower

Cauliflower is recommended for breast cancer

Like broccoli, cabbage, and brussels sprouts, cauliflower is a brassica (cruciferous) vegetable. While cauliflower contains fewer vitamins and minerals than most other brassica vegetables, it contains numerous substances with suspected or demonstrated cancer fighting properties, including iberin, sinigrin, choline, indole-3-carbinol (I3C), 3,3'-diindolylmethane (DIM), and several other glucosinolates. Cauliflower or its components have been shown to inhibit urinary bladder, small intestine, colorectal and liver carcinogenesis, and reduce the risk of occurrence of gallbladder, prostate, lung, urothelial, and cervical cancer.

Cauliflower and its component molecules have been found to be promote apoptosis, suppress cell cycle progression and inhibit angiogenesis of human breast cancer cells. Furthermore, cauliflower can protect against cell DNA damage. Consumption of brassica vegetables has been shown to reduce the estrogen metabolite 16alpha-hydroxyestrone, which is a breast cancer promoter, and to be marginally inversely associated with breast cancer risk in a population of premenopausal women. Cauliflower component I3C has been shown increase the anti-cancer effects of the chemotherapy drug Taxol (paclitaxel).

We recommend consuming the cancer-fighting components of cauliflower and other brassica vegetables as food and against consuming them as "broccoli pills" that have been enhanced to boost the proportion of the presumed key anti-cancer chemicals in these vegetables. There is some evidence that concentrated cruciferous vegetable extracts can act as estrogen agonists and promote breast cancer cell proliferation. Also, the anticancer properties of cauliflower are likely to be the result of synergistic interaction of its various chemical components - isolated components have successfully inhibited proliferation in the laboratory, but their efficacy and safety in humans needs to be evaluated in large scale clinical trials.

Below are links to recent studies concerning this food. For a more complete list of studies, please click on cauliflower.

Tags: cauliflower, DIM, estrone, I3C, iodine, isothiocyanates, paclitaxel, proliferation, Taxol, thyroid

Health Promoting Effects of Brassica-Derived Phytochemicals: From Chemopreventive and Anti-Inflammatory Activities to Epigenetic Regulation Fruit and vegetable intake and breast cancer risk defined by estrogen and progesterone receptor status: the Japan Public Health Center-based Prospective Study Sulforaphane inhibits mammary adipogenesis by targeting adipose mesenchymal stem cells Metastasis of Breast Tumor Cells to Brain Is Suppressed by Phenethyl Isothiocyanate in a Novel In Vivo Metastasis Model Post-diagnosis Cruciferous Vegetable Consumption and Breast Cancer Outcomes: a Report from the After Breast Cancer Pooling Project Cruciferous vegetables intake is inversely associated with risk of breast cancer: A meta-analysis The Indole-3-carbinol Cyclic Tetrameric Derivative CTet Synergizes with Cisplatin and Doxorubicin in Triple-negative Breast Cancer Cell Lines I3C and ICZ inhibit migration by suppressing the EMT process and FAK expression in breast cancer cells Indole-3-Carbinol disrupts Estrogen Receptor-alpha dependent expression of Insulin-like Growth Factor-1 Receptor and Insulin Receptor Substrate-1 and proliferation of human breast cancer cells Diindolilmethane (DIM) selectively inhibits cancer stem cells Analysis of total glucosinolates and chromatographically purified benzylglucosinolate in organic and conventional vegetables Low concentrations of isothiocyanates protect mesenchymal stem cells from oxidative injuries, while high concentrations exacerbate DNA damage Cruciferous vegetables and cancer risk in a network of case-control studies The Safety of Cruciferous Plants in Humans: A Systematic Review Highly pigmented vegetables: Anthocyanin compositions and their role in antioxidant activities Effect of different sample preparation methods on isoflavone, lignan, coumestan and flavonoid contents of various vegetables determined by triple quadrupole LC-MS/MS Natural isothiocyanates: Genotoxic potential versus chemoprevention

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