Brussels sprouts
are
highly recommended for breast cancer
Brussels sprouts have been shown to suppress inflammation and can reduce the risk of occurrence of multiple myeloma, as well as gallbladder, prostate, lung, ovarian, cervical and colorectal cancer.
Breast cancer-related effects of
eating
brussels sprouts
Brussels sprouts contain numerous substances with suspected or demonstrated cancer fighting properties, including beta-carotene, sulforaphane, indole-3-carbinol (I3C), 3,3'-diindolylmethane (DIM), and several other glucosinolates. Brussels sprouts are also a good source of the lignan enterolactone. Brussels sprouts have been found to be promote apoptosis, suppress cell cycle progression and inhibit angiogenesis of human breast cancer cells. Futhermore, brussels sprouts can protect against cell DNA damage. Consumption of brassica vegetables has been shown to reduce the estrogen metabolite 16alpha-hydroxyestrone, which is a breast cancer promoter, and to be marginally inversely associated with breast cancer risk in a population of premenopausal women. Brussels sprouts components I3C and sulforaphane have both been shown increase the anti-cancer effects of the chemotherapy drug Taxol (paclitaxel). The kaempferol in brussels sprouts might help protect against the cardiotoxicity of Adriamycin chemotherapy.
Additional comments
We recommend consuming brussels sprouts and other brassica vegetables as food and against consuming broccoli pills that have been enhanced to boost the proportion of the presumed key anti-cancer chemicals in these vegetables. There is some evidence that concentrated cruciferous vegetable extracts can act as estrogen agonists and promote breast cancer cell proliferation. Also, the anticancer properties of broccoli are likely to be the result of synergistic interaction of its various chemical components - isolated components have successfully inhibited proliferation in the laboratory, but their efficacy and safety in humans needs to be evaluated in large scale clinical trials.
Cruciferous vegetables contain thioglucoside compounds that can interfere with the formation of thyroid hormone.
Tags:
DIM,
I3C,
Indole-3-carbinol,
Taxol,
angiogenesis,
betaCarotene,
brusselsSprouts,
carotenoids,
cervicalCancer,
chemotherapy,
enterolactone,
estrone,
inflammation,
iodine,
isothiocyanates,
kaempferol,
lignan,
ovarianCancer,
paclitaxel,
proliferation,
sulforaphane,
thyroid
Benzyl Isothiocyanate Causes FoxO1-Mediated Autophagic Death in Human Breast Cancer Cells
Cruciferous vegetables and cancer risk in a network of case-control studies
Carotenoid intakes and risk of breast cancer defined by estrogen receptor and progesterone receptor status: a pooled analysis of 18 prospective cohort studies
Natural isothiocyanates: Genotoxic potential versus chemoprevention
Kaempferol protects against doxorubicin-induced cardiotoxicity in vivo and in vitro
Serum enterolactone levels and mortality outcome in women with early breast cancer: a retrospective cohort study
Mechanisms of action of isothiocyanates in cancer chemoprevention: an update
Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice
Serum enterolactone and postmenopausal breast cancer risk by estrogen, progesterone and HER2 receptor status
Fruit and Vegetable Intake in Relation to Risk of Breast Cancer in the Black Womens Health Study
Glucoraphanin hydrolysis by microbiota in the rat cecum results in sulforaphane absorption
p53-Independent Apoptosis by Benzyl Isothiocyanate in Human Breast Cancer Cells Is Mediated by Suppression of XIAP Expression
Regulation of estrogen receptor α expression in human breast cancer cells by sulforaphane
Indole-3-carbinol inhibits MDA-MB-231 breast cancer cell motility and induces stress fibers and focal adhesion formation by activation of Rho kinase activity
Consumption of Brussels sprouts protects peripheral human lymphocytes against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and oxidative DNA-damage: results of a controlled human intervention trial
Proteome alterations induced in human white blood cells by consumption of Brussels sprouts: Results of a pilot intervention study
Glucosinolate Changes in Blanched Broccoli and Brussels Sprouts
3,3'-Diindolylmethane is a novel mitochondrial H(+)-ATP synthase inhibitor that can induce p21(Cip1/Waf1) expression by induction of oxidative stress in human breast cancer cells
Post-initiation treatment of Indole-3-carbinol did not suppress N-methyl-N-nitrosourea induced mammary carcinogenesis in rats
Estrogenic Effects of Extracts from Cabbage, Fermented Cabbage, and Acidified Brussels Sprouts on Growth and Gene Expression of Estrogen-Dependent Human Breast Cancer (MCF-7) Cells
Brassica vegetable consumption shifts estrogen metabolism in healthy postmenopausal women
The effect of a diet rich in brussels sprouts on warfarin pharmacokinetics