blueberries

Blueberries are highly recommended for breast cancer

Blueberries rank among the highest of all fruits and vegetables in the capacity to destroy free radicals. Blueberries contain caffeic acid, catechin, chlorogenic acid, epicatechin, ferulic acid, gallic acid, kaempferol, myricetin, naringenin, p-coumaric acid, p-hydroxybenzoic acid, pterostilbene, resveratrol, quercetin, and ursolic acid, most of which have been reported to have anti-cancer properties.

Breast cancer-related effects of eating blueberries

Blueberries have been found to inhibit mammary cancer cell proliferation in mice and rats, as well as inhibiting cultured cancer cell growth in the laboratory and blood vessel tumors in rats. Pterostilbene has been shown to inhibit obesity-related breast cancer growth and proliferation in the laboratory and to have additive treatment effects when combined with tamoxifen in estrogen receptor positive (ER+) breast cancer cells. Pterostilbene also has been shown to reduce the formation of breast cancer stem cells and inhibit their metastatic activities.

Blueberries are a good source of resveratrol, which has been shown to increase the effects of radiation, aromatase inhibitors and the chemotherapy drug Taxol (paclitaxel) against breast cancer.

Blueberry extract has been shown to exhibit antitumor activity against MDA-MB-231 triple negative breast cancer cells and reduce their metastatic potential. Blueberry was found to inhibit cell proliferation in triple negative cells with no effect on normal breast cells in one study. Blueberry also reduced the metastatic potential of triple negative cells through inhibition of cell motility.

In animal studies, dietary blueberry has been shown to reduce triple negative tumor volume in female mice. Blueberry diets reduced triple negative proliferation (as measured by Ki-67) and increased cell death. In addition, a blueberry diet inhibited triple negative tumor metastasis in another mouse study. Analysis of tumor tissues has demonstrated that blueberry-fed mice tumors have significantly altered expression of genes important to inflammation, cancer, and metastasis.

Additional comments

The antioxidant properties of blueberries have been shown to be reduced when eaten with milk, suggesting that the best way to gain maximum benefits from blueberries and other fruits eaten for their polyphenol content is to consume them either one hour before or two hours after protein is consumed.

Non-organic blueberries must be washed very thoroughly to remove pesticide residue as much as possible.

Bilberries, which grow wild in much of northern Europe, are closely related to blueberries. They are valued for their high flavonoid content.

Below are links to recent studies concerning this food. For a more complete list of studies, please click on blueberries.

Tags: aromataseActivity, aromataseInhibitors, blueberry, kaempferol, milk, naringenin, paclitaxel, proanthocyanidins, proliferation, quercetin, radiationTreatment, resveratrol, Taxol

Selected breast cancer studies

Evaluation of protective effect of myricetin, a bioflavonoid in dimethyl benzanthracene-induced breast cancer in female Wistar rats Resveratrol prevents p53 core domain aggregation Whole Blueberry Powder Inhibits Metastasis of Triple Negative Breast Cancer in a Xenograft Mouse Model Through Modulation of Inflammatory Cytokines Delphinidin inhibits cell proliferation and induces apoptosis in MDA-MB-231 human breast cancer cell lines Chemopreventive and therapeutic activity of dietary blueberry against estrogen-mediated breast cancer Resveratrol enhances chemosensitivity of doxorubicin in multidrug-resistant human breast cancer cells via increased cellular influx of doxorubicin Anticancer effects of bioactive berry compounds Proteomic Profiling Reveals That Resveratrol Inhibits HSP27 Expression and Sensitizes Breast Cancer Cells to Doxorubicin Therapy Ursolic acid promotes cancer cell death by inducing Atg5-dependent autophagy Cytotoxicity and apoptosis induction in human breast adenocarcinoma MCF-7 cells by (+)-cyanidan-3-ol Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF-κB/microRNA 448 circuit Intake of specific fruits and vegetables in relation to risk of estrogen receptor-negative breast cancer among postmenopausal women Anti-estrogenic activity of a human resveratrol metabolite Resveratrol decreases breast cancer cell viability and glucose metabolism by inhibiting 6-phosphofructo-1-kinase Resveratrol activates the histone H2B ubiquitin ligase, RNF20, in MDA-MB-231 breast cancer cells Invadopodia-associated proteins blockade as a novel mechanism for 6-shogaol and pterostilbene to reduce breast cancer cell motility and invasi Triterpenoid Content of Berries and Leaves of Bilberry Vaccinium myrtillus from Finland and Poland Cytotoxic Effect of Natural trans-Resveratrol Obtained from Elicited Vitis vinifera Cell Cultures on Three Cancer Cell Lines Resveratrol induces downregulation of DNA repair genes in MCF-7 human breast cancer cells Inhibition of estrogen-mediated mammary tumorigenesis by blueberry and black raspberry Effects of resveratrol on paclitaxel-sensitive and -resistant triple negative breast cancer cells Ellagic acid, a phenolic compound, exerts anti-angiogenesis effects via VEGFR-2 signaling pathway in breast cancer Influence of Berry-Polyphenols on Receptor Signaling and Cell-Death Pathways: Implications for Breast Cancer Prevention



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