Many women experience weight gain during chemotherapy and endocrine treatment for breast cancer. This is especially true of patients who were not overweight before diagnosis. Weight gain has been found to be associated with increased risk of death among survivors. The evidence suggests that women should monitor their weight and avoid weight gain after a diagnosis of breast cancer. Adopting a breast cancer diet customized to their breast cancer subtype would accomplish this goal for most women since the majority of recommended foods are not fattening. Whether losing weight after diagnosis improves prognosis is an open question.
Weight gain is common during breast cancer treatment
The popular view is that cancer results in spontaneous weight loss, but this typically occurs only if the cancer has metastasized. Nevertheless, for most women, the weight gain after breast cancer is modest - one study estimated that a weight gain of more than 22 lbs takes place in fewer than 10% of breast cancer survivors. Women with significant levels of systemic inflammation (as evidenced by elevated circulating C-reactive protein) at diagnosis are more likely to gain body fat over the following year. Unfortunately, both weight gain and increases in the proportion of body fat heighten inflammation (which promotes breast cancer development) even more.
Which women gain weight during treatment?
Chemotherapy-induced weight gain tends to be particularly pronounced in premenopausal women and normal weight women. In addition, unfavorable changes in body composition (including loss of lean and increase in fat tissue) can occur even without weight gain. One study reported that younger women and women who were underweight or normal weight at the time of cancer diagnosis were the most likely to gain weight and to experience increases in percent body fat. Average weight gain varies according to the type of chemotherapy regimen. A large minority of women, including some whose weight was stable during treatment, also experience progressive weight gain in the years after treatment.
However, note that one 2012 study reported that weight loss during anthracycline chemotherapy was associated with poorer survival in women with early-stage breast cancer than stable weight.
How much weight do women gain over time?
One U.S. study that examined weight gain among women aged 40 to 54 who received chemotherapy reported that women of normal weight gained an average of 4.3 pounds during the first year. On the other hand, overweight women lost an average of 3.0 pounds and obese women lost 4.1 pounds. Neither overweight nor obese women experienced a proportionate increase in body fat. Reduced physical activity was associated with weight gain. Younger age and treatment with tamoxifen were associated with increased fat mass in the torso.
Another study followed Chinese stage 0-III breast cancer survivors for three years after diagnosis. The median weight change was only 2.2 lbs six months after diagnosis. However, approximately 26% of the women gained at least 5% of their at-diagnosis body weight during the first six months and 33% gained at least 5% by 36 months post-diagnosis. Greater weight gain was found among women who had lower body mass index (BMI) at diagnosis, had more advanced disease stage, were younger, were premenopausal, or who had been treated with chemotherapy or radiation treatment during the first six months after cancer diagnosis.
One study examined weight changes over three years among premenopausal women undergoing endocrine therapy (tamoxifen or the aromatase inhibitor Arimidex) while also undergoing ovarian suppression. BMI was found to increase in both the tamoxifen and Arimidex study arms after one, two and three years of treatment. The increase was significantly higher in patients treated with tamoxifen compared to Arimidex after one, two and three years (BMI increase of 1.10 compared to 0.74 kg/mē after three years).
Another U.S. study examined weight gain during chemotherapy by type of regimen. The most common regimens of patients in the study were docetaxel/cyclophosphamide (TC) and doxorubicin/cyclophosphamide followed by paclitaxel (dose-dense AC-T). Weight changes differed significantly between regimens. Women receiving TC gained 2.8 lbs, on average, whereas those on dose dense AC-T lost 1.2 lbs.
Weight gain after developing breast cancer worsens prognosis
The majority of studies that have investigated the influence of weight gain after diagnosis have concluded that weight gain reduces survival compared to no weight gain:
- A 2015 U.S. study reported that women with ER+ disease who had a pre- to post-diagnosis weight gain (measured at approximately the two-year mark) of at least 10% were more likely to experience late recurrence (more than five years after diagnosis) of breast cancer.
- A U.S. study investigated the effects of weight gain on survival among 1,436 women diagnosed with breast cancer during 1996 or 1997. The women, who were followed through year-end 2005, were interviewed soon after diagnosis and approximately five years later. Weight was recorded for each decade of adult life, in addition to one year before diagnosis, at diagnosis, one year after diagnosis, and at the end of follow up. Compared with those who remained within 5% of their prediagnosis weight, women who gained more than 10% were 2.7 times less likely to survive. This effect was more pronounced during the first two years after diagnosis, among women who had been overweight before diagnosis, and for women who had gained at least 3 kg (6.6 lbs) in adulthood before diagnosis.
- A large prognostic Chinese study including 5,042 breast cancer patients aged 20 to 75 reported that women who gained at least 5 kg (11 lbs) had higher mortality than those who maintained their weight after diagnosis. The women were followed for a median of 46 months.
- A meta-analysis that combined data from four prospective studies reported that, when compared to women who remained weight stable (within 6.6 lbs of pre-diagnosis weight), women who experienced a significant weight gain after a diagnosis of breast cancer were more likely to die. However, the observed increase in breast cancer-specific death was not statistically significant. The increased likelihood of overall death associated with large weight gain was predominantly seen in women whose pre-diagnosis BMI was < 25.
- A study that included 5,204 Nurses' Health Study participants who were diagnosed with breast cancer between 1976 and 2000 reported that among never-smoking women, those whose BMI increased by more than 2.0 kg/m(2) (median gain, 17.0 lbs) had 1.64 times the risk of breast cancer-specific death as women who maintained their weight during a median follow-up period of nine years. Associations with weight were stronger in premenopausal than in postmenopausal women. Similar findings were noted for breast cancer recurrence and all-cause mortality.
Does losing weight after a diagnosis of breast cancer improve outcome?
Generally speaking, studies have not focused on the impact of weight loss on breast cancer prognosis. This is because significant intentional weight loss during the first year after diagnosis is relatively rare. Any weight loss that does occur could be the result of as yet undetected metastatic disease.
Two studies have attempted to determine whether losing weight would improve survival of initially obese breast cancer patients by using mouse models of breast cancer. Mammary tumor growth in the formerly obese mice was found to be significantly higher than in control mice who had never been obese. This was despite the fact that the formerly obese mice had lost all of their excess weight before being implanted with tumor cells. Achieving normal weight might not be sufficient to reverse the effects of long-term obesity on epigenetic changes and inflammatory signals in the tumor microenvironment that promote breast cancer progression.
Please see our article on how to optimize your breast cancer diet for information on what to eat during all stages of treatment and recovery.
Below are links to recent studies on obesity or gaining weight after treatment and survival. For a more complete list of studies, please click on the tag BMI.